Influenza Antivirals (Pan Flu Preparedness for LHDs, Session 5)
Fee: none
Length: 15 minutes
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This presentation, developed by Richard Rosselli, MPH, gives you an overview of influenza antiviral medications.
Target Audience
These learning modules are applicable to all public health, medical, veterinary, pharmacy, emergency management, hospital and other professionals interested in public health preparedness. These modules are created by faculty and guest lecturers at the UNC Gillings School of Global Public Health.
Educational Objectives
- Describe the two classes of antivirals
- Understand the difference between treatment and prophylaxis
- Understand antiviral resistance
- Describe the role of antivirals in pandemics, including distribution plans and prioritization
- Understand the ethical issues involving pandemic antiviral use
Competencies and Capability Functions Addressed
This training addresses selected applied epidemiology, core public health, and public health preparedness and response competencies and public health preparedness capability functions as noted below. (Please note: The following training does not provide comprehensive or in-depth treatment of specified competencies or capability functions, it provides basic knowledge of the competencies or capability functions listed below.)
| Applied Epidemiology Competencies Tier 1 |
| Use knowledge of human and environmental biology and behavioral sciences and principles to determine potential biological mechanisms of disease (II.A.2) |
| Respond to public health emergencies (VII.F.3) |
| Applied Epidemiology Competencies Tier 2 |
| Use knowledge of human and environmental biology and behavioral sciences and principles to determine potential biological mechanisms of disease (II.A.2) |
| Core Competencies for Public Health Professionals |
| 4) Applies the basic public health sciences (including, but not limited to biostatistics, epidemiology, environmental health sciences, health services administration, and social and behavioral health sciences) to public health policies and programs (6: Basic Public Health Sciences Skills) |
| Public Health Preparedness & Response Core Competencies |
| 3.2. Contribute expertise to the development of emergency plans. |
| 4.2. Employ protective behaviors according to changing conditions, personal limitations, and threats. |
References
1. Oseltamivir: cutaneous and neurological adverse effects in children. Prescrire Int. Oct 2006;15(85):182-183.
2. BuranathaiC, AmonsinA, ChaisighA, TheamboonlersA, PariyothornN, PoovorawanY. Surveillance activities and molecular analysis of H5N1 highly pathogenic avian influenza viruses from Thailand, 2004-2005. Avian Dis. Mar 2007;51(1 Suppl):194-200.
3. MontoAS, McKimm-BreschkinJL, MackenC, et al. Detection of influenza viruses resistant to neuraminidase inhibitors in global surveillance during the first3 years of their use. Antimicrob Agents Chemother. Jul 2006;50(7):2395-2402.
4. OngAK, Hayden FG. John f. Enders lecture 2006: antiviralsfor influenza. J Infect Dis. Jul 15 2007;196(2):181-190.
5. KisoM, MitamuraK, Sakai-TagawaY, et al. Resistant influenza A viruses in children treated with oseltamivir: descriptive study. Lancet. Aug 28-Sep 3 2004;364(9436):759-765.
6. de JongMD, Tran TT, Truong HK, et al. Oseltamivirresistance during treatment of influenza A (H5N1) infection. N Engl J Med. Dec 22 2005;353(25):2667-2672.
7. GubarevaLV, MatrosovichMN, Brenner MK, BethellRC, Webster RG. Evidence for zanamivirresistance in an immunocompromisedchild infected with influenza B virus. J Infect Dis. Nov 1998;178(5):1257-1262.
8.Hayden FG, Pavia AT. Antiviral management of seasonal and pandemic influenza. J Infect Dis. Nov 1 2006;194 Suppl2:S119-126.
9. HatakeyamaS, SugayaN, Ito M, et al. Emergence of influenza B viruses with reduced sensitivity to neuraminidase inhibitors. Jama. Apr 4 2007;297(13):1435-1442.
10. IlyushinaNA, BovinNV, Webster RG, GovorkovaEA. Combination chemotherapy, a potential strategy for reducing the emergence of drug-resistant influenza A variants. Antiviral Res. Jul 2006;70(3):121-131.
11. GaniR, Hughes H, Fleming D, Griffin T, Medlock J, Leach S. Potential impact of antiviral drug use during influenza pandemic. Emerg Infect Dis. Sep 2005;11(9):1355-1362.
12. DHHS. HHS pandemic influenza plan, Appendix D: NVAC/ACIP recommendations for prioritization of pandemic influenza vaccine and NVAC recommendations on pandemic
Author and Narrator:
Reviewer:
Jennifer Horney, MPH
The author(s) and reviewer(s) of this training have no personal financial relationships with commercial interests relevant to this presentation to disclose.
Continuing Education Credit:
The UNC Center for Public Health Preparedness offers the following continuing education credit/s on this training. Eligibility for all continuing education credit is determined on an annual basis.
- none
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Disclaimer/Disclosure
To Access and Complete This Training:
To register for a login and password, click on the Registration Form link. If you have already registered, click on our Already Registered link. If you are returning to this training, please click the Resume Training link. Please read over the information on this page first.